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Press release from Linköping University.
Lyme disease and the immune system
Patients who become chronically sick after a Lyme disease have a different type of immune response compared to patients who are healthy after using antibiotics.Lyme disease, an infection transmitted by tick bites, affects people differently. Some become completely healthy after antibiotic treatment, others get chronic co
mplaints. The disease is characterized by several stages and can affect several organs. In the first stage, there is a local skin infection. Stage two attacks the nervous system, joints and heart. In the third stage, the disease has become chronic. What matters for the disease heals or goes on to the next stage is largely unknown in humans, but animal studies have shown that various immunological reactions may influence disease outcome.
Mona Widhe, biologist at the Department of Molecular and Clinical Medicine, Linköping University, in her thesis examined the nature of the immune response in humans has any bearing on how Lyme disease infection develops, ie, if it heals, or if it develops into a chronic disease.
She has found signs that some patients receiving chronic variant - chronic neurological Lyme disease - have a different type of immune response compared to patients who are healthy after using antibiotics. The same pattern can also be seen in patients with a chronic infection of the skin caused by Lyme disease, compared to those who only get the classic circular rash.
Results suggest that the type of immune response is an important factor affecting borreliainfektionens propensity to develop into a chronic disease. That knowledge can at best be the basis for that in the future through 'immunomodulatory therapy to prevent chronic symptoms.
Press release from Linköping University.
Contact Lennart Falklöf
013-28 16 93
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